Year: 2023
Type: article
Abstract: The advent of single-cell transcriptomics has provided biologists an unprecedented opportunity to capture previously unappreciated cell states.With the discovery of different cell states has come an imperative to name and characterize the function of these cell states.In the lung, many of these cell states appear during periods of local or organ-wide transition-both during organogenesis and in the attempt to repair the lung after injury.In this new single-cell transcriptomics world, there has been a rapid increase in manuscripts reporting the discovery and naming of these in-between states (1-5).Indeed, this major technical innovation has heralded a return to the ancient science of taxonomy and a sense that the state of the field is, as the song "Stuck in the Middle with You" by Stealers Wheel aptly describes, "all over the place" as we try to make "sense of it all" (6) by naming, and occasionally renaming, previously unappreciated cell types.Over time, the approach used to describe, name, and characterize these
DOI: 10.1172/jci174633
Institutions: Vanderbilt University, Vanderbilt University Medical Center
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,200
Awards: Mechanisms of epithelial repair and remodeling in pulmonary fibrosis, Wnt Signaling in Bronchopulmonary Dysplasia, Integrated Molecular and Cellular Drivers of Alveologenesis, Spatiotemporal genomic regulation of disease initiation and progression in pulmonary fibrosis, Interdisciplinary Training Program in Lung Research
OpenAlex ID: W4388698894