Stem Cell Therapy: A Possible Role in the Treatment of Patients with Chronic Limb-Threatening Ischemia?
Year: 2023
Type: article
Study design: Case Report
Abstract: Chronic limb-threatening ischemia (CLTI) is a severe form of peripheral arterial disease that portends high morbidity and mortality. Patients may undergo various endovascular or open procedures with the goal of limb salvage. No-option CLTI patients represent a vulnerable population for whom conventional options have been exhausted, or anatomy precludes any attempts at revascularization, often resulting in amputation. Stem cell therapy is under investigation for these no-option CLTI patients. Regardless of revascularization technique, these patients are clinically challenging and require multidisciplinary efforts to achieve the best outcomes. Here we present a patient with unfavorable anatomy who underwent stem cell therapy injection for a nonhealing right first toe wound, and we include points to remember when considering stem cell treatment in patients with CLTI.
DOI: 10.14797/mdcvj.1291
Authors: Annabella Olson, Bright Benfor, Eric Peden
Institution: Houston Methodist
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4388730553