FIGURE 3 from Exogenous Sequences in Tumors and Immune Cells (Exotic): A Tool for Estimating the Microbe Abundances in Tumor RNA-seq Data
Year: 2023
Type: other
Abstract: Network-based exploration of microbe–gene interactions. A, Summary of the correlations between all microbes and all genes, selecting only the correlations significant in both datasets and where the effect direction agrees. B, Consistent correlations are further filtered for the 5% most extreme values and then used to build a network for which the number of edges per node follows a power-law distribution. C, The top taxa by degree centrality are shown, which include those with precedence for affecting cancer outcomes (Bifidobacterium), as well as microbes that have only been described in the gut (Alistipes). Each microbe shows a distinct pattern of gene relationships (colored lines), suggesting a variety of interaction types. D, Examples of pathway enrichment analyses of the genes interacting with microbes include Alistipes finegoldii, Bifidobacterium bifidum, and a strain of Pseudomonas.
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4388861817