FIGURE 2 from Exogenous Sequences in Tumors and Immune Cells (Exotic): A Tool for Estimating the Microbe Abundances in Tumor RNA-seq Data
Year: 2023
Type: other
Abstract: Estimating the clinical relevance of observed tumor microbes through the concordance between two independent datasets. A, Survival analyses by cancer stratified by microbe presence/absence at every taxonomic level. Colors indicate a significant association with survival. The ORIEN and TCGA analyses separately show many significant associations, whereas few are consistent (significant and affecting survival in the same direction) across both datasets. B, Examples of two taxa that show concordant associations between the two datasets. C, Microbes correlate with representative clinical variables and an expression signature of the tumor microenvironment (Buffa hypoxia score). Shown are concordant correlations for ORIEN and TCGA data, except for BMI, which is missing in TCGA for many cancers. D, Correlation of microbes with deconvolved immune cell abundances within each cancer.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4388865848