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Autophagy deficiency protects against ocular hypertension and glaucoma

Year: 2023

Type: article

Abstract: mice, this latter generated in our laboratory via CRISPR/Cas9 technology, which display impaired autophagy. In contrast to littermate WT controls, mice deficient in Atg4B, did not develop glaucomatous elevation of intraocular pressure (IOP). Moreover, autophagy deficiency protected against RGC death and optic nerve atrophy. Collectively, our data supports a pathogenic role of autophagy in the context of ocular hypertension and glaucoma.

Source: Autophagy Reports

DOI: 10.1080/27694127.2023.2285214