Empirically derived psychosocial‐behavioral phenotypes in Black/African American and Hispanic/Latino older adults enrolled in HABS‐HD: Associations with AD biomarkers and cognitive outcomes
Year: 2023
Type: article
Abstract: INTRODUCTION: Identification of psychosocial-behavioral phenotypes to understand within-group heterogeneity in risk and resiliency to Alzheimer's disease (AD) within Black/African American and Hispanic/Latino older adults is essential for the implementation of precision health approaches. METHODS: A cluster analysis was performed on baseline measures of socioeconomic resources (annual income, social support, occupational complexity) and psychiatric distress (chronic stress, depression, anxiety) for 1220 racially/ethnically minoritized adults enrolled in the Health and Aging Brain Study-Health Disparities (HABS-HD). Analyses of covariance adjusting for sociodemographic factors examined phenotype differences in cognition and plasma AD biomarkers. RESULTS: The cluster analysis identified (1) Low Resource/High Distress (n = 256); (2) High Resource/Low Distress (n = 485); and (3) Low Resource/Low Distress (n = 479) phenotypes. The Low Resource/High Distress phenotype displayed poorer cognition and higher plasma neurofilament light chain; differences between the High Resource/Low Distress and Low Resource/Low Distress phenotypes were minimal. DISCUSSION: The identification of psychosocial-behavioral phenotypes within racially/ethnically minoritized older adults is crucial to the development of targeted AD prevention and intervention efforts.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.13544
Authors: Alexandra L. Clark, Kelsey R. Thomas, Nazareth Ortega, Andreana P. Haley, Audrey Duarte, Sid O'Bryant, for the HABS‐HD Study Team
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,000
Awards: Heterogeneity of subtle cognitive decline phenotypes in community-dwelling older adults, Health Disparities in Alzheimer's Disease Among Mexican Americans, Identifying best methods for the detection of subtle cognitive decline, Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican Americans, G665855531, The impact of segregation and the mediating effects of vascular risk on 10-year cognitive and functional outcomes in Black/African American older adults enrolled in the ACTIVE study, Amyloid Burden among Mexican Americans, Laboratory of Neuro Imaging Resource (LONIR), UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, Health and Aging Brain among Latino Elders (HABLE-AT(N)) Study, The Health & Aging Brain Study - Health Disparities (HABS-HD)
OpenAlex ID: W4388921921