Work

GRK4, A Potential Link between Hypertension and Breast Cancer.

Year: 2022

Type: article

Abstract: Hypertension and breast cancer are two common diseases occurring in women. Clinical studies have shown increased breast cancer incidence in hypertensive women. Several lines of evidence demonstrate that G protein-coupled Receptor Kinase 4 (GRK4) could be a common risk factor for hypertension and breast cancer. This article reviews our current understanding of molecular mechanisms of GRK4 in hypertension and breast cancer.

Source: PubMed

Authors: Wei Yue, John J Gildea, Peng Xu, Robin A Felder

Institution: University of Virginia Health System

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Molecular Mechanisms in Salt Sensitivity of Blood Pressure, Renal dopamine-1 receptor defect in hypertension, D2 receptor variation and renal dysfunction