Work

Photoinduced cerium-catalyzed C–H acylation of unactivated alkanes

Year: 2023

Type: article

Abstract: )-H bonds using bench-stable acyl azolium reagents under mild and operationally-friendly conditions. This reaction exhibits excellent generality, accommodating a wide range of feedstock chemicals such as cycloalkanes and acyclic compounds as well as facilitating the late-stage functionalization of pharmaceuticals. We demonstrate further applications of our strategy with a three-component radical relay reaction and an enantioselective N-heterocyclic carbene (NHC) and cerium dual-catalyzed reaction.

Source: Chemical Science

DOI: 10.1039/d3sc05162e

Authors: Jing Cao, Joshua L. Zhu, Karl A. Scheidt

Institution: Northwestern University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Northwestern University, National Institute of General Medical Sciences

Award: G749739012