Effect of chronic kidney disease induced calcification on peripheral vascular perfusion using near-infrared spectroscopic imaging
Year: 2023
Type: article
Abstract: Low-cost techniques that can detect the presence of vascular calcification (VC) in chronic kidney disease (CKD) patients could improve clinical outcomes. In this study, we established a near-infrared spectroscopy-based imaging technique to determine changes in peripheral hemodynamics due to CKD-induced VC. Mice were fed a high-adenine diet with either normal or high levels of phosphate to induce CKD with and without VC, respectively. The mice tail was imaged to evaluate hemodynamic changes in response to occlusion. The rate of change in oxyhemoglobin in response to occlusion showed a statistically significant difference in the presence of VC in the mice.
Source: Biomedical Optics Express
DOI: 10.1364/boe.503667
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,913
Awards: Correlating Aortic Valve Structure to Heart Sound Characteristic, Development of tissue oxygenation indices for acute wounds and diabetic foot ulcers using near-infrared imaging approach, NSF Engineering Research Center for Precise Advanced Technologies and Health Systems for Under-resourced Populations (PATHS-UP), Targeting the Caveolae-Dependent Mechanism of Calcifying Extracellular Vesicle Formation
OpenAlex ID: W4389057867