Work

Stem cells treatment in chronic ischemic heart disease: a narrative review.

Year: 2023

Type: review

Abstract: values from 0.05 to 0.0001). No significant differences in LVEF were observed between patients who underwent intracoronary or intramyocardial transplantation. NYHA class decrease from severe to mild/moderate was demonstrated in 10 trials reporting a significant LVEF increase. Patients transplanted with bone marrow and peripheral blood CD133+ stem cells showed a doubling of percentage LVEF increase in comparison to patients transplanted with CD133- cells. This narrative review reports the conflicting results on this topic. Multicenter randomized clinical trials should be performed to define the efficacy of stem cells transplantation in chronic ischemic heart disease.

Source: PubMed Central

Authors: Roberto G Carbone, Simone Negrini, Giuseppe Murdaca, Vincenzo Fontana, Francesco Puppo

Institutions: University of Genoa, Ospedale Policlinico San Martino

Language: English

Topic: Mesenchymal stem cell research

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Medical Research Council

OpenAlex ID: W4389178828