Design and implementation of the hospital airway resuscitation trial
Year: 2023
Type: article
Abstract: Guidelines for the management of in-hospital cardiac arrest resuscitation are often drawn from evidence generated in out-of-hospital cardiac arrest populations and applied to the in-hospital setting. Approach to airway management during resuscitation is one example of this phenomenon, with the recommendation to place either a supraglottic airway or endotracheal tube when performing advanced airway management during in-hospital cardiac arrest based mainly in clinical trials conducted in the out-of-hospital setting. The Hospital Airway Resuscitation Trial (HART) is a pragmatic cluster-randomized superiority trial comparing a strategy of first choice supraglottic airway to a strategy of first choice endotracheal intubation during resuscitation from in-hospital cardiac arrest. The design includes a number of innovative elements such as a highly pragmatic design drawing from electronic health records and a novel primary outcome measure for cardiac arrest trials-alive-and-ventilator free days. Many of the topics explored in the design of HART have wide relevance to other trials in in-hospital cardiac arrest populations.
Source: Resuscitation Plus
Authors: Ari Moskowitz, Luke Andrea, Ariel L. Shiloh, John Cardasis, Colleen Carty, Mimi Kim, Xianhong Xie, Susan McAllen, David Esses, Carlo Lutz, Mai Takematsu, Jose Romero, Kristen Schimmrich, Daniel G. Fein, Amos E. Dodi, Samuel Rednor, Maneesha Bangar, Amira Mohamed, Lewis A. Eisen, Henry E. Wang, Michael W. Donnino, Michelle Ng Gong
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,100
Award: G614048844
OpenAlex ID: W4389201707