Work

IP8: A quantitatively minor inositol pyrophosphate signaling molecule that punches above its weight

Year: 2023

Type: review

Abstract: The inositol pyrophosphates (PP-IPs) are specialized members of the wider inositol phosphate signaling family that possess functionally significant diphosphate groups. The PP-IPs exhibit remarkable functionally versatility throughout the eukaryotic kingdoms. However, a quantitatively minor PP-IP – 1,5 bisdiphosphoinositol tetrakisphosphate (1,5-IP8) – has received considerably less attention from the cell signalling community. The main purpose of this review is to summarize recently-published data which have now brought 1,5-IP8 into the spotlight, by expanding insight into the molecular mechanisms by which this polyphosphate regulates many fundamental biological processes.

Source: Advances in Biological Regulation

DOI: 10.1016/j.jbior.2023.101002

Authors: Chunfang Gu, Xingyao Li, Guangning Zong, Huanchen Wang, Stephen B. Shears

Institutions: National Institutes of Health, National Institute of Environmental Health Sciences

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,880

Funders: Georgetown University, National Institutes of Health, National Institute of Environmental Health Sciences