Work

Cardiovascular dysfunction induced by combined exposure to nicotine inhalation and high-fat diet

Year: 2023

Type: article

Abstract: Nicotine product usage and high-fat diet consumption are two modifiable risk factors for cardiovascular diseases. Here, we demonstrate that in mice, combined exposure to inhaled nicotine and high-fat diet results in unique cardiovascular consequences compared with either treatment alone, including left ventricular diastolic dysfunction, dysregulation of blood pressure, autonomic dysfunction, and greater impairment of endothelium-dependent vasorelaxation. These findings indicate that individuals who consume both nicotine products and high-fat diet have distinctive cardiovascular risks.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00474.2023

Authors: Anna K. Whitehead, Zhen Li, Kyle B. LaPenna, Nour Abbes, Thomas E. Sharp, David J. Lefer, Eric Lazartigues, Xinping Yue

Institutions: Louisiana State University Health Sciences Center New Orleans, Southeast Louisiana Veterans Health Care System

Language: English

Topic: Cardiovascular Function and Risk Factors

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, American Heart Association, National Heart, Lung, and Blood Institute

Awards: G1806432799, G2117053523, G2813049024, Hydrogen Sulfide Regulation in Cardioprotection, G4197134577, Endogenous Hydrogen Sulfide Enzymes in Heart Failure, Chronic nicotine inhalation increases susceptibility to cardiovascular and pulmonary diseases through inhibition of local compensatory mechanisms, G5370448186, G567987502, G644951250, Roles of Endothelial and Smooth Muscle KATP Channels in Myocardial Ischemic Injury, E-cigarette Inhalation and Cardiopulmonary Dysfunction, G94808082

OpenAlex ID: W4389244185

FWCI: 1.181

Cites: 66

Cited by: 6

Related to: 10