CD62L expression marks a functionally distinct subset of memory B cells
Year: 2023
Type: article
Abstract: The memory B cell response consists of phenotypically distinct subsets that differ in their ability to respond upon antigen re-encounter. However, the pathways regulating the development and function of memory B cell subsets are poorly understood. Here, we show that CD62L and CD44 are progressively expressed on mouse memory B cells and identify transcriptionally and functionally distinct memory B cell subsets. Bcl6 is important in regulating memory B cell subset differentiation with overexpression of Bcl6 resulting in impaired CD62L + memory B cell development. Bcl6 regulates memory B cell subset development through control of a network of genes, including Bcl2 and Zeb2 . Overexpression of Zeb2 impairs the development of CD62L + memory B cells. Importantly, CD62L is also differentially expressed on human memory B cells following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and identifies phenotypically distinct populations. Together, these data indicate that CD62L expression marks functionally distinct memory B cell subsets.
Source: Cell Reports
Institution: Washington University in St. Louis
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,460
Funders: Ministry of Education, Culture, Sports, Science and Technology, National Institutes of Health, Washington University School of Medicine in St. Louis, Center for Cellular Imaging, Washington University, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences
Awards: G103575219, G1160089588, Enhancing the antiviral memory B cell response, G4102728913, G5571277077, G5982071039, G5990125371, G7059131728, G7527623597, National Research Service Award-Medical Scientist, G80801781, Lung-resident memory B cell development and function following influenza virus infection, DYNAMICS AND EVOLUTION OF IMMUNE RESPONSES TO INFLUENZA VIRUSES, Programming Durable Immune Responses To Vaccination, Washington University Institute of Clinical and Translational Sciences, G921956316
OpenAlex ID: W4389331704