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FIGURE 2 from Temporary Knockdown of p53 During Focal Limb Irradiation Increases the Development of Sarcomas

Year: 2023
Type: other
Abstract: Temporary reduction of p53 during irradiation increases chronic injuries in subsets of mice. A, Kaplan–Meier curves show acute injury-free survival (score 1+) of control and p53KD male and female mice irradiated with 40 Gy to the hind limb. P value is from a log-rank test. B, Kaplan–Meier curves show acute injury-free survival (score 1+) of control and p53KD male and female mice irradiated with 30 Gy to the hind limb. P value is from a log-rank test. Kaplan–Meier curves show chronic injury-free survival from scores 1+ (C), 2+ (D), 3+ (E), or 4 (F) of control and p53KD male and female mice irradiated with 30 Gy to the hind limb. P value is from a log-rank test.
DOI: 10.1158/2767-9764.24746691.v1
Authors: Andrea R. Daniel, Chang Su, Nerissa T. Williams, Zhiguo Li, Jianguo Huang, Omar Lopez, Lixia Luo, Yan Ma, Lorraine da Silva Campos, Sara R. Selitsky, Jennifer L. Modliszewski, Siyao Liu, Rosa Hernansaiz-Ballesteros, Yvonne M. Mowery, Diana M. Cardona, Chang-Lung Lee, David G. Kirsch
Language: English
Field: Medicine
Open Access status: gold
OpenAlex ID: W4389336007
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