Microbial Primer: In vivo biofilm
Year: 2023
Type: article
Abstract: In this primer on biofilms and their role in infections, we trace the historical roots of microbial understanding from Van Leeuwenhoek’s observations to Bill Costerton’s groundbreaking work, which solidified biofilms' significance in infections. In vivo biofilm research, investigating patient samples and utilizing diverse host models, has yielded invaluable insights into these complex microbial communities. However, it comes with several challenges, particularly regarding replicating biofilm infections accurately in the laboratory. In vivo biofilm analyses involve various techniques, revealing biofilm architecture, composition, and behaviour, while gaps in knowledge persist regarding infection initiation and source, diversity, and the Infectious Microenvironment (IME). Ultimately, the study of biofilms in infections remains a dynamic and evolving field poised to transform our approach to combat biofilm-associated diseases.
Source: Microbiology
DOI: 10.1099/mic.0.001407
Authors: Kendra P. Rumbaugh, Thomas Bjarnsholt
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4389338607