Association of Prenatal Maternal and Infant Vitamin D Supplementation with Offspring Asthma
Year: 2023
Type: article
Abstract: Rationale The role and timing of vitamin D supplementation in the prevention of asthma has not been fully elucidated. Objective To describe the association between prenatal and postnatal vitamin D with offspring asthma outcomes in participants of the Vitamin D Antenatal Asthma Reduction Trial. Methods We classified 748 mother–offspring pairs into four groups based on the mother’s randomization to receive high-dose versus low-dose (4,400 IU vs. 400 IU) vitamin D supplementation during pregnancy and the offspring parent-reported high-dose versus low-dose (⩾400 IU vs. <400 IU) vitamin D supplementation as estimated by intake of vitamin D drops or infant formula. We used logistic regression to test the association of the four vitamin D exposure groups—“mother-low/infant-low (reference),” “mother-high/infant-high,” “mother-high/infant-low,” and “mother-low/infant-high”—with offspring asthma and/or recurrent wheeze at age 3 years, active asthma at age 6 years, and atopic asthma at age 6 years. Results The risk of asthma and/or recurrent wheeze at 3 years was lowest in the mother-high/infant-low group (adjusted odds ratio vs. mother-low/infant-low, 0.39; 95% confidence interval, 0.16–0.88, P = 0.03). When stratifying by history of exclusive breastfeeding until age 4 months, the protective effect in the mother-high/infant-low group was seen only among exclusively breastfed infants (odds ratio vs. mother-low/infant-low, 0.19; 95% confidence interval, 0.04–0.68; P = 0.02). We did not observe any significant associations with active or atopic asthma at age 6 years. Conclusions We observe that high-dose prenatal and low-dose postnatal vitamin D supplementation may be associated with reduced offspring asthma or recurrent wheeze by age 3 years, but this association may be confounded by the protective effect of breastfeeding.
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Multi-omic approaches to mechanisms of vitamin D, environmental influences, and the microbiome on asthma, RANDOMIZED CONTROLLED TRIAL: VDAART CONTINUATION STUDY - DCC - LEAD, Multi-Omics Analysis of the Association of Polyunsaturated Fatty Acids with Asthma and Allergy in Childhood, G4730798529, Multi-Omic Endotyping of Asthma, Environmental Agents as Modulators of Disease Processes, SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES
OpenAlex ID: W4389397413