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Supplemental Figure 14 from Infusion Product TNFα, Th2, and STAT3 Activities Are Associated with Clinical Responses to Transgenic T-cell Receptor Cell Therapy

Year: 2023
Type: supplementary-materials
Abstract: Acellular CD4 secretion levels of IL-4 and IL-5 are associated with inferior clinical response to transgenic TCR-T cell therapy. Association of acellular CD4 secretion levels of IL-4 with clinical response (A) and percent change in tumor burden per RECIST 1.1 criteria (B). Association of bulk CD4 secretion levels of IL-5 with clinical response (C) and percent change in tumor burden per RECIST 1.1 criteria (D). * p<0.05, **p<0.01, unpaired t-test.
DOI: 10.1158/2326-6066.24764973
Authors: Theodore S. Nowicki, Cole W. Peters, Crystal Quiros, Conner K. Kidd, Moe Kawakami, Alexandra M. Klomhaus, Ignacio Baselga-Carretero, Paula Kaplan-Lefko, Mignonette H. Macabali, Ivan Perez Garcilazo, Beata Berent-Maoz, Begoña Comin-Anduix, Antoni Ribas
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: gold
OpenAlex ID: W4389431190
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