Polygonatum odoratum lectin promotes BECN1 expression and induces autophagy in malignant melanoma by regulation of miR1290
Year: 2017
Type: article
Abstract: : Autophagy is not only a survival response to growth-factor or nutrient deprivation but also an important mechanism for tumor-cell suicide, including melanoma. Polygonatum odoratum lectin (POL) displays apoptosis- and autophagy-inducing effects in many human tumors. POL also inhibits the growth of melanoma cells, but its role and molecular mechanism in malignant melanoma remain unclear. In this study, we found that POL suppressed proliferation and induced autophagy in melanoma cells. miR1290 was upregulated and inhibited autophagy in melanoma. BECN1 is the direct functional effector of miR1290. Furthermore, we found that POL promoted BECN1 expression though inhibition of miR1290, thus inducing melanoma-cell autophagy. This finding elucidates a new role and mechanism for POL in melanoma, and provides a potential antineoplastic agent for melanoma treatment. Keywords: autophagy, Polygonatum odoratum lectin, miR1290, BECN1 , melanoma
Source: OncoTargets and Therapy
DOI: 10.2147/ott.s147406
Authors: Wenkang Luan, Yao Qian, Xin Ni, Tonmoy Kumar Chanda, Yun Xia, Jinlong Wang, Yulan Yan, Bin Xu
Institutions: Jiangsu University, Affiliated Hospital of Jiangsu University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,836
Funder: Jiangsu University
Award: G1093836201
OpenAlex ID: W2754469548