Work

Pioneering use of genetic analysis for CDH1 to identify candidates for prophylactic total gastrectomy to prevent hereditary diffuse gastric cancer

Year: 2023

Type: article

Abstract: Worldwide, gastric cancer results in significant morbidity and mortality. Ten per cent of patients with gastric cancer have a strong family history of the disease. CDH1 (E-cadherin) has been identified as a key gene whose mutation leads to hereditary diffuse gastric cancer. We overviewed 33 articles with prophylactic total gastrectomy and assessed the outcomes and benefits. Families with mutations in CDH1 may benefit from early prophylactic total gastrectomy. Dr Mark Duncan has applied his experience as a high-volume gastric cancer surgeon to treat not only individual patients, but several generations of patients within a family. This use of prophylactic total gastrectomy is well tolerated by patients and prevents the future development of gastric cancer.

Source: eGastroenterology

DOI: 10.1136/egastro-2023-100017

Authors: Farzad Mokhtari-Esbuie, Bryan Szeglin, Mohsen Rouhani Ravari, Mark Duncan, John W Harmon

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital, University of Chicago

Language: English

Topic: Gastric Cancer Management and Outcomes

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Johns Hopkins University, National Heart, Lung, and Blood Institute