Work

Monitoring Melanoma Responses to STING Agonism and Focused Ultrasound Thermal Ablation Using Microneedles and Ultrasensitive Single Molecule Arrays (Adv. Funct. Mater. 50/2023)

Year: 2023

Type: article

Abstract: Ultrasensitive Single Molecule Arrays In article number 2301659, Natalie Artzi and co-workers show that engineered polymeric microneedles enable sampling of biomarkers in skin interstitial fluid in response to melanoma treatment with combination immunoablative therapy—focused ultrasound thermal ablation and nanoparticulate stimulator of interferon genes agonism. Subsequent microneedle-derived biomarker processing via ultrasensitive single-molecule arrays afford effective detection of proinflammatory biomarkers in the femtomolar range.

Source: Advanced Functional Materials

DOI: 10.1002/adfm.202370295

Authors: Daniel Dahis, Michelle Z. Dion, Alexander M. Cryer, Pere Dosta, Tal Gilboa, Mariana Alonso, Michael Lewandowski, Núria Puigmal, Gonzalo Muñoz Taboada, Haim Azhari, Rushdy Ahmad, David R. Walt, Natalie Artzi

Institutions: Brigham and Women's Hospital, Harvard University, Technion – Israel Institute of Technology, Wyss Institute for Biologically Inspired Engineering, Massachusetts Institute of Technology, Harvard–MIT Division of Health Sciences and Technology, Broad Institute

Language: English

Topic: Advancements in Transdermal Drug Delivery

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4389508541

FWCI:

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