Work

Exploring the Effect of Eligibility Criteria on AD Severity and Severe Adverse Event in Eligible Patients

Year: 2023

Type: conference-paper

Abstract: Clinical trials were vital tools to prove the effectiveness and safety of medications. To maximize generalizability, the study sample should represent the sample population and the target population. However, the clinical trial design tends to favor the evaluation of drug safety and procedure (i.e., internal validity) without clear knowledge of its penalty on trial generalizability (i.e., external validity). Alzheimer's Disease (AD) trials are known to have generalizability issues. Thus, in this study, we explore the effect of eligibility criteria on the AD severity patients and the severe adverse event (SAE) among the eligible patients.

Source: IEEE International Conference on Healthcare Informatics (ICHI)

DOI: 10.1109/ichi57859.2023.00139

Authors: Aokun Chen, Qian Li, Elizabeth Shenkman, Yonghui Wu, Yi Guo, Jiang Bian

Institution: University of Florida

Language: English

Topic: Statistical Methods in Clinical Trials

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Aging, National Cancer Institute