Work

Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by co-chaperone carboxyl-terminus of Hsp70 interacting protein in adipose-derived stem cells provide augmented cardioprotection in aging-hypertensive rats

Year: 2023

Type: article

Abstract: ) into nine months aging-SHR led to an increase in their cardiac function - increased ejection fraction and fractional shortening (≈15% vs. control SHR) - as well as a decrease in their heart size and heart rate, respectively. Altogether, our results support the use of CHIP overexpressing stem cells for the mitigation of cardiac hypertrophy and remodeling associated with late-stage hypertension.

Source: Aging

DOI: 10.18632/aging.205287

Authors: Parthasarathi Barik, Wei-Wen Kuo, Chia-Hua Kuo, Dennis Jine-Yuan Hsieh, Cecilia Hsuan Day, Jayasimharayalu Daddam, Michael Yu-Chih Chen, V. Vijaya Padma, Marthandam Asokan Shibu, Chih-Yang Huang

Institutions: China Medical University, University of Taipei, Chung Shan Medical University Hospital, Chung Shan Medical University, Meiho University, Tzu Chi Foundation, Buddhist Tzu Chi General Hospital, Bharathiar University, Asia University, Tzu Chi University, China Medical University Hospital

Language: English

Topic: Heat shock proteins research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Ministry of Science and Technology, Taiwan

Awards: G5634652733, Screening of Efficient Chinese Herbal Medicines That Augment the Beneficial Effects of Short-Term Hypoxia Pre-Conditioning and the Therapeutic Mirnas and Exosomes of Mesenchymal Stem Cells in Treating Primary Hypertension Associated Cardiac Damages, G939887807

OpenAlex ID: W4389548579

FWCI: 0.226

Cites: 41

Cited by: 3

Related to: 10