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Combined repetitive inhalant endotoxin and collagen-induced arthritis drive inflammatory lung disease and arthritis severity in a testosterone-dependent manner

Year: 2023
Type: article
Abstract: Our study shows that testosterone acts as a key immunomodulatory hormone contributing to critical features of rheumatoid arthritis (RA)-associated lung disease in the setting of airborne endotoxin (lipopolysaccharide; LPS) exposures and concomitant arthritis induction in mice. The exaggerated airway inflammation observed following combined exposures in male mice was accompanied by increases in profibrotic mediators, netosis, and increased expression of lung autoantigens, all relevant to the pathogenesis of lung disease in arthritis.
DOI: 10.1152/ajplung.00221.2023
Authors: Jill A. Poole, Geoffrey M. Thiele, Elizabeth Ramler, Amy J. Nelson, Michael J. Duryee, Aaron D. Schwab, Angela Gleason, Carlos D. Hunter, Rohit Gaurav, Todd A. Wyatt, Bryant R. England, Ted R. Mikuls
Language: English
Subfield: Rheumatology
Field: Medicine
Open Access status: hybrid
Funders: U.S. Department of Defense, U.S. Department of Veterans Affairs, Rheumatology Research Foundation, National Institute on Alcohol Abuse and Alcoholism, National Institute of General Medical Sciences, National Institute for Occupational Safety and Health
Awards: G1069647005, G1600607514, G1725699813, G173497652, G2023642720, G2840147328, G6445281850, Alcohol Center Of Research -- Nebraska (ACORN), Great Plains IDeA-CTR
OpenAlex ID: W4389607634
FWCI: 2.996
Cites: 37
Cited by: 15
Related to: 10