Work

In vivo CAR T cell tumor control assay v1

Year: 2023

Type: preprint

Abstract: This protocol describes methods for a HCC1954 cell implanted orthotopic tumor model in mice with delivery of T cells expressing HER2 CAR. Tumor volumes are measured to evaluate tumor control by CAR T cell therapy.

DOI: 10.17504/protocols.io.yxmvm3qj6l3p/v1

Authors: Sean R. McCutcheon, Adam M. Swartz, Michael C. Brown, Alejandro Barrera, Christian McRoberts Amador, Keith Siklenka, Lucas Humayun, Maria A. ter Weele, James M. Isaacs, Andrea R Daniel, Timothy E. Reddy, Andrew S. Allen, Smita K. Nair, Scott J. Antonia, Charles A. Gersbach

Institution: Duke University

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4389608237

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