Work

Perspective—Assessing Electrochemical, Aptamer-Based Sensors for Dynamic Monitoring of Cellular Signaling

Year: 2023

Type: article

Abstract: Electrochemical, aptamer-based (E-AB) sensors provide a generalizable strategy to quantitatively detect a variety of targets including small molecules and proteins. The key signaling attributes of E-AB sensors (sensitivity, selectivity, specificity, and reagentless and dynamic sensing ability) make them well suited to monitor dynamic processes in complex environments. A key bioanalytical challenge that could benefit from the detection capabilities of E-AB sensors is that of cell signaling, which involves the release of molecular messengers into the extracellular space. Here, we provide a perspective on why E-AB sensors are suited for this measurement, sensor requirements, and pioneering examples of cellular signaling measurements.

Source: ECS Sensors Plus

DOI: 10.1149/2754-2726/ad15a1

Authors: Celeste R. Rousseau, Hope Kumakli, Ryan J. White

Institution: University of Cincinnati

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,350

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke