Work

Development of therapeutic cancer vaccines using nanomicellar preparations

Year: 2023

Type: article

Abstract: Cancer treatment is a multifaceted challenge, and therapeutic vaccines have emerged as a promising approach. The micellar preparation efficiently encapsulates antigen polypeptides and enhances antigen presentation through the major histocompatibility class I pathway, promoting cytotoxic T lymphocyte immune responses. Moreover, it enables codelivery of both antigen and adjuvant to the same target antigen-presenting cells. Combining the micellar vaccine with traditional cancer treatments (such as chemotherapy, radiotherapy, and surgery) has demonstrated improved efficacy in murine tumor models. Overall, the polyethylene glycol–phosphatidylethanolamine micelle-based vaccine presents a promising platform for cancer therapeutic vaccines. By leveraging the strengths of various treatment modalities, this innovative vaccine approach holds the potential to revolutionize cancer therapy and bring new possibilities for cancer patients.

Source: Oncology and Translational Medicine

DOI: 10.1097/ot9.0000000000000014

Authors: Yan Qin, Wen-Feng Zeng, Wei Liang

Institutions: Chinese Academy of Sciences, Institute of Biophysics, University of Chinese Academy of Sciences

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4389727517

FWCI: 1.138

Cites: 24

Cited by: 13

Related to: 10