Work

Proteolysis-targeting chimeras with reduced off-targets

Year: 2023

Type: article

Source: Nature Chemistry

DOI: 10.1038/s41557-023-01379-8

Authors: Tuan M. Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K. Tiwari, Katherine A. Donovan, Veronika Shoba, Santosh K. Chaudhary, Jaron A. M. Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S. Fischer, David R. Liu, Benjamin L. Ebert, Amit Choudhary

Institutions: Broad Institute, Brigham and Women's Hospital, Harvard University, Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Defense, Howard Hughes Medical Institute, U.S. Department of Health and Human Services, Broad Institute, National Institutes of Health, Defense Advanced Research Projects Agency, National Human Genome Research Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering

Awards: G1037014486, G1187679441, 'MULTIDIMENSIONAL CHEMOGENIC CONTROL OF CRISPR- NUCLEASES IN CELLS AND ORGANISMS', G1973200330, G2304256781, Development of synthetic gene drives using small molecules, Chemical approaches for precision genome editing, G4630203202, G4883975104, G5052434461, G52289035, G5232001575, G6078497061, G6316350344, G6623355810, G691306909, Continuous Evolution of Proteins with Novel Therapeutic Potential, Degrading therapeutically important kinases using small molecules, G7095660139, G7486275663, G8120716183, G8649764646, Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics, G9000034423, G9000083182, G9000117671, G9000195109, The molecular basis of IMiD induced neo-substrate recruitment to the CRL4CRBN ubiquitin E3 ligase, ePACE: automation platforms for adaptable and scalable continuous evolution of biomolecules with therapeutic potential, G962928493

OpenAlex ID: W4389894233

FWCI: 10.07

Cites: 41

Cited by: 139

Related to: 10