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Leptomeningeal Immunoglobulin G4–Related Disease: A Case Report

Year: 2023

Type: article

Abstract: We present the case of an older man with history of rheumatoid arthritis, taking etanercept who developed focal neurologic deficits with imaging findings that raised concern for central nervous system neoplasia, as well as a nondiagnostic initial brain biopsy. Imaging showed left hemispheric leptomeningeal enhancement, as well as left frontal convexity rim-enhancing collections, suspicious for abscess. Empiric antibiotics did not improve the patient's condition, and a second central nervous system biopsy revealed a diagnosis of leptomeningeal immunoglobulin G4–related disease, a rare fibroinflammatory condition. Awareness of this condition, prompt diagnosis, and treatment are imperative to prevent irreversible organ damage, disability, and potentially death.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2023.0907

Authors: Cesar Simbaqueba, Ashley Aaroe, David Rubio, Monica Loghin, Jeffrey Treiber, Leomar Ballester, Gregory Fuller, Sricharan Gopakumar, Betty Yon Son Kim, Maria Suarez-Almazor

Institutions: The University of Texas MD Anderson Cancer Center, Baylor College of Medicine

Language: English

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4389941332

FWCI: 0.175

Cites: 15

Cited by: 1

Related to: 10