Work

High Incidence Rate of Computed Tomography–Measured Steatotic Liver Disease in Men With and Without HIV Infection

Year: 2023

Type: article

Study design: Observational Study

Abstract: INTRODUCTION: We determined steatotic liver disease (SLD) incidence in a prospective cohort of men with HIV (MWH) and men without HIV (MWOH). METHODS: Incident SLD was defined using paired noncontrast computed tomography scans performed during 2010-2013 and repeated during 2015-2017. RESULTS: Of 268 men, 173 MWH and 95 MWOH, 33 had incident SLD (11.1%, incidence rate 2.4 and 2.7/100 person-years for MWH and MWOH, respectively). Overall, higher abdominal visceral adipose tissue was independently associated with increased SLD risk. In MWH, increased visceral adipose tissue, insulin resistance, chronic hepatitis B, and cumulative etravirine use were associated with SLD. DISCUSSION: Metabolic factors, but not HIV, were associated with incident SLD. The high incidence rate suggests that SLD will continue to increase in PWH.

Source: The American Journal of Gastroenterology

DOI: 10.14309/ajg.0000000000002633

Authors: Jennifer C. Price, Gayle Springer, Eric C. Seaberg, Matthew J. Budoff, Susan L. Koletar, Claudia A. Hawkins, Mallory D. Witt, Wendy S. Post, Chloe L. Thio

Institutions: University of California, San Francisco, Johns Hopkins University, The Lundquist Institute, The Ohio State University, Northwestern University, University of California, Los Angeles, Harbor–UCLA Medical Center, Johns Hopkins Medicine

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences

Awards: G1400602301, Translational Biomedical Science Training Grant, G1655989834, G1773452051, G183157880, G192128497, G2127051194, G248584506, G2755707676, G2759654445, G2839061624, G30074556, G319781266, G3242306066, G3418878615, G343705321, G483408255, G5431849782, G5747858550, University of Miami Developmental HIV/AIDS Mental Health Research Center (D-ARC), G672796319, G693265041, G703764079, Subclinical Vascular Disease and Metabolic Abnormalities in MACS, Progression of Coronary Atherosclerosis in MACS, Johns Hopkins Institute for Clinical and Translational Research, G9000010044, University of Pittsburgh MACS/WIHS CCS, MACS/WIHS -CCS, The Johns Hopkins Center for AIDS Research (JHU CFAR), UNC MACS/WIHS Combined Cohort Study Clinical Research Site, Surviving the HIV Epidemic (S/HE) in metropolitan Washington DC - Advancing knowledge through cohort studies, Center for AIDS Research at Emory University, Data Analysis and Coordination Center for the MACS-WIHS Combined Cohort Study, The University of North Carolina Center for AIDS Research, MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS), Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center, UAB-MISS MACS/WIHS Combined Cohort Study, UCLA Clinical and Translational Science Institute, Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS), UAB Center for AIDS Research (CFAR)

OpenAlex ID: W4390120706

FWCI:

Cites: 14

Cited by:

Related to: 10