Work

Rational Design and Synthesis of an Artificial Enzyme for SN2 Reactions through Micellar Imprinting

Year: 2023

Type: article

Abstract: The rational design of catalysts with enzyme-like properties is an elusive goal of chemists despite tremendous interest. Molecular imprinting inside surfactant micelles, followed by postmodification, creates a tailored active site in a water-soluble polymeric "artificial enzyme" for the benzylation of 4-nitrophenol. The reaction happens under neutral conditions with excellent substrate selectivity. Similar to many enzymes, electrostatics play vital roles in catalysis and can be tuned through different bases introduced into the active site.

Source: Organic Letters

DOI: 10.1021/acs.orglett.3c03666

Authors: Foroogh Bahrami, Yan Zhao

Institution: Iowa State University

Language: English

Topic: Analytical chemistry methods development

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: Artificial Glycosidase with Controlled Selectivity