Year: 2023
Type: article
Abstract: has historically been used as traditional medicine in Asia and Europe for its potential benefits in fighting infection and cancer. It has gained interest in the neurodegenerative disease field because of its mechanisms of action; these include anti-inflammation, neuroprotection, and promoting neurite growth demonstrated in various cell and animal models. A very small, double-blind, placebo-controlled trial in patients with mild cognitive impairment showed a temporary improvement in cognitive function; this finding has yet to be replicated. However, there have been no studies in ALS cell or animal models or in humans with ALS. Lion's Mane appears safe and inexpensive when consumed in powder or capsule, but one anaphylactic case was reported after a patient consumed fresh Lion's Mane mushroom. Currently, we do not have enough information to support the use of Lion's Mane for treating ALS. We support further research in ALS disease models and clinical trials to study its efficacy.
Authors: Maya Muhanna, Issac Lund, Mark Bromberg, Paul Wicks, Michael Benatar, Benjamin Barnes, Kaitlyn Pierce, Dylan Ratner, Andrew Brown, Tulio Bertorini, Paul Barkhaus, Greg Carter, Javier Mascias Cadavid, Christopher McDermott, Jonathan D Glass, Gary Pattee, Carmel Armon, Richard Bedlack, Xiaoyan Li
Institutions: Augusta University, University of Utah, University of Miami, University of North Carolina at Chapel Hill, Tulane University, University of Tennessee Health Science Center, Medical College of Wisconsin, Washington State University Spokane, University of Sheffield, Emory University, University of Nebraska Medical Center, Assaf Harofeh Medical Center, Duke University
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: ALS Association
Award: ALSUntangled
OpenAlex ID: W4390143166