Work

Cenicriviroc prevents dysregulation of astrocyte/endothelial cross talk induced by ischemia and HIV-1 via inhibiting the NLRP3 inflammasome and pyroptosis

Year: 2023

Type: article

Abstract: The present study reveals the role of astrocytic NOD-like receptor protein-3 (NLRP3) inflammasome in dysfunctional astrocyte-endothelial cross interactions triggered in response to oxygen/glucose deprivation injury associated with human immunodeficiency virus type 1 (HIV-1) infection. Our results suggest that blocking NLRP3 inflammasome activation and pyroptosis-mediated inflammation with cenicriviroc (CVC) may constitute a potentially effective therapeutic strategy for blood-brain barrier (BBB) protection during HIV-1-associated ischemic stroke.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00600.2023

Authors: Nikolai Fattakhov, Alex Ngo, Silvia Torices, Joelle-Ann Joseph, Adesuwa Okoro, Cameron Moore, Oandy Naranjo, Sarah Becker, Michal Toborek

Institution: University of Miami

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Allergy and Infectious Diseases

Awards: G1056143923, G1309373569, G5431849782, G5943719250, G628684116, Novel role of inflammasome activation in ART neurotoxicity, G7224178199, Targeting Inflammasomes in Substance Abuse and HIV, G897712522, HIV-1 and amyloid beta interactions at the blood-brain barrier, Defining brain pericytes as a novel and myeloid-derived HIV reservoir

OpenAlex ID: W4390197019

FWCI: 1.638

Cites: 116

Cited by: 22

Related to: 10