Year: 2023
Type: article
Abstract: INTRODUCTION: Early risk stratification for clinical dementia could lead to preventive therapies. We identified and validated a magnetic resonance imaging (MRI) signature for Alzheimer's disease (AD) and related dementias (ARDR). METHODS: An MRI ADRD signature was derived from cortical thickness maps in Framingham Heart Study (FHS) participants with AD dementia and matched controls. The signature was related to the risk of ADRD and cognitive function in FHS. Results were replicated in the University of California Davis Alzheimer's Disease Research Center (UCD-ADRC) cohort. RESULTS: Participants in the bottom quartile of the signature had more than three times increased risk for ADRD compared to those in the upper three quartiles (P < 0.001). Greater thickness in the signature was related to better general cognition (P < 0.01) and episodic memory (P = 0.01). Results replicated in UCD-ADRC. DISCUSSION: We identified a robust neuroimaging biomarker for persons at increased risk of ADRD. Other cohorts will further test the validity of this biomarker.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.13600
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,000
Awards: G11426272, G1217552590, G1221127345, UC Davis Alzheimer's Disease Core Center, Heterogeneity of Mild Cognitive Impairment (MCI), Microglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE Consortium, Therapeutic target discovery in ADSP data via comprehensive whole-genome analysis incorporating ethnic diversity and systems approaches, G250621538, G2630878680, G278200998, Multidimensional Assessment of Brain Health as A Marker of Dementia Risk and Resilience, G3205625555, G3241505316, G3405256882, Mitochondrial DNA Copy Number and Sequence Variation in Relation to Age, Alzheimer's Disease Related Phenotypes and Age-related Metabolic Traits, ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model Systems, G4684857399, G4727311221, G4976486911, Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham Cohorts, G511441455, The impact of non-amyloid processes on cognitive aging, G5277573023, Preclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young Adults, G5600171757, G6076595154, G6281193135, The Framingham Heart Study, G6614798878, Multiethnic Validation of VCID biomarkers in South Texas, G7108272716, G7257611415, G7264467602, G755502235, G7992751642, G8326557007, Plasma Proteome and Risk of Alzheimer Dementia and Related Endophenotypes in the Framingham Study, Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC), The San Antonio Heart and Mind Study, Multiethnic Validation of VCID Biomarkers in South Texas, UC Davis Alzheimer's Disease Research Center, Precursors of Stroke Incidence and Prognosis, Brain pathologies, reserve and cognition in aging and dementia, South Texas Alzheimer's Disease Center
OpenAlex ID: W4390237420