Aspergillus fumigatus strains that evolve resistance to the agrochemical fungicide ipflufenoquin in vitro are also resistant to olorofim
Year: 2023
Type: article
Abstract: Widespread use of azole antifungals in agriculture has been linked to resistance in the pathogenic fungus Aspergillus fumigatus. We show that exposure of A. fumigatus to the agrochemical fungicide, ipflufenoquin, in vitro can select for strains that are resistant to olorofim, a first-in-class clinical antifungal with the same mechanism of action. Resistance is caused by non-synonymous mutations within the target of ipflufenoquin/olorofim activity, dihydroorotate dehydrogenase (DHODH), and these variants have no overt growth defects.
Source: Nature Microbiology
Institutions: University of Manchester, F2G (United Kingdom)
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $11,690
Awards: Determining the role of inter-kingdom interactions in the evolution of antimicrobial resistance, Evolution and adaptation of human fungal pathogens to a warming world, G339059223, Understanding and mitigating the impact of emerging antifungal resistance, The Aspergillus fumigatus gene and non-coding RNA knockout library, Understanding the eco-evolutionary drivers of emerging antifungal resistance, G7202444299
OpenAlex ID: W4390273837