Year: 2023
Type: article
Study design: Observational Study
Abstract: Objectives Determine if biomarkers of Alzheimer's disease and neural injury may play a role in the prediction of delirium risk. Methods In a cohort of older adults who underwent elective surgery, delirium case‐no delirium control pairs (N = 70, or 35 matched pairs) were matched by age, sex and vascular comorbidities. Biomarkers from CSF and plasma samples collected prior to surgery, including amyloid beta (Aβ)42, Aβ40, total (t)‐Tau, phosphorylated (p)‐Tau181, neurofilament‐light (NfL), and glial fibrillary acid protein (GFAP) were measured in cerebrospinal fluid (CSF) and plasma using sandwich enzyme‐linked immunosorbent assays (ELISAs) or ultrasensitive single molecule array (Simoa) immunoassays. Results Plasma GFAP correlated significantly with CSF GFAP and both plasma and CSF GFAP values were nearly two‐fold higher in delirium cases. The median paired difference between delirium case and control without delirium for plasma GFAP was not significant (p = 0.074) but higher levels were associated with a greater risk for delirium (odds ratio 1.52, 95% confidence interval 0.85, 2.72 per standard deviation increase in plasma GFAP concentration) in this small study. No matched pair differences or associations with delirium were observed for NfL, p‐Tau 181, Aβ40 and Aβ42. Conclusions These preliminary findings suggest that plasma GFAP, a marker of astroglial activation, may be worth further investigation as a predictive risk marker for delirium.
DOI: 10.1002/gps.6044
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Delirium, Dementia, and the Vulnerable Brain: An Integrative Approach, Mid-Career Mentoring Award for Patient-Oriented Research in Aging, Polygenic Risk and Inflammation in Delirium and Alzheimer's disease, Genetic and Inflammatory Mechanisms of Delirium and Alzheimer's Disease, Shared Pathophysiology of Postoperative Delirium and Alzheimer's Disease and Related Dementias, Brain Vulnerability in Delirium and Alzheimer’s Disease and Related Dementias: Intersection of Polygenic Risk and Inflammation, AD/ADRD and biological aging proteomic signatures in the etiopathology of delirium and its associated long-term cognitive decline, Massachusetts Alzheimer's Disease Research Center (MADRC), READI-SET-GO: Researching Efficient Approaches to Delirium Identification - Sustaining Effective Translation to create Gero-friendly Organizations
OpenAlex ID: W4390484587