Figure S1 from Tyrosine Kinase Inhibition Activates Intratumoral γδ T Cells in Gastrointestinal Stromal Tumor
Year: 2024
Type: other
Abstract: Supplemental Figure S1. (A) Alternate gating strategy for identifying γδ T cells in KitV558Δ/+ tumors by flow cytometry (B) Prevalence of γδ T cells as a percentage of T cells in KitV558Δ/+ mice across multiple anatomic compartments. (C) Percent of cells positive for IFNγ in KitV558Δ/+ tumor by flow cytometry after intracellular cytokine stimulation. (D) Histograms of flow cytometry staining for the transcription factors T-bet and EOMES in T cells from KitV558Δ/+ tumors. (E) Vγ2 expression in tumor and spleen γδ T cells from KitV558Δ/+ mice. Representative of 4 mice. Data represent mean ± SEM; p values were calculated using a two-sided Student’s t test; *, P < 0.05.
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4390544103