O0106 the Incidence and Prevalence of Pediatric Inflammatory Bowel Disease (ibd) in the Usa
Year: 2004
Type: conference-abstract
Abstract: Introduction: Paucity of population-based data exits on the incidence and prevalence of IBD in North American children. IBD is one of the most common chronic gastrointestinal disorders with substantial morbidity in childhood. More reliable estimation and continued monitoring of incidence and prevalence of pediatric IBD [both Crohn’s disease (CD) and ulcerative colitis (UC)] may shed light on its causes. Further, pediatric CD and UC may qualify for Federal Drug Administration (FDA)’s orphan drug trials in the USA, if the documented prevalence rates are less than 200,000. Recently, we (WI pediatric IBD Alliance) published the incidence of CD and UC in children over a two-year period 2000–01 in a large population based model (J Pediatrics 2003;143: 525–31). We continued the monitoring of the incidence rate in the state of WI beyond that period to date. Our aim was to estimate the prevalence of IBD in children in the USA by two separate methods using the data from WI. Methods: All pediatric GI physicians (n =22) providing care for WI children voluntarily identified all new cases of IBD beginning in year 2000. In addition, all the pediatric IBD cases in South East (SE) WI (13 counties out of 72 counties in WI) were also identified to assess the prevalence of IBD in children in a defined local area. Data from the 2000 U.S Census was used to determine the population characteristics. Incidence rates were calculated per million pediatric populations per year, and the 95% confidence intervals (CI) were estimated assuming a negative binomial model. The over all prevalence rates for WI and USA were calculated using statistical models based on age and race. Results: Wisconsin had 5.4 million people, and 26% of the total state population was children younger than age 18. In 2000–02, 315 new cases were diagnosed throughout the entire state. In addition, 528 established cases of IBD children are being followed in SE WI by 12 GI physicians. The overall incidence of IBD was calculated as 7.5 (6.9 – 8.3, 95% CI) per 100,000. Using the incidence data, the estimated prevalence for the state of WI and USA were 676 +/−131 and 35,287 +/−6828 respectively. The estimate of the prevalence is obtained by assuming the incidence per each year is fairly constant, together with the patients in the oldest category “graduating” into adult IBD, and no longer being part of prevalent pediatric IBD population. Applying the local prevalent data, the estimated prevalence for the state of WI and USA were 993 +/−86 and 64587+/−5600 respectively. Conclusion: Our first attempt to estimate the prevalence rate of IBD among US children on a population based data gives a figure between 35–65,000. This prevalence rate qualifies pediatric CD and UC for FDA’s orphan drug trials in the USA.
Authors: S. Kugathasan, R. Hoffmann, Wisconsin Pediatric IBD Alliance
Institution: Medical College of Wisconsin
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4390568334