Year: 2024
Type: editorial
Abstract: 6 months, with reconstitution recovering only after a year.Furthermore, a high level of PD-1 + T cells at baseline was associated with impaired disease control, in direct contrast to the profile observed with I+R.Given these correlative associations in relation to treatment allocation, the team next looked at potential underlying mechanisms of cellular function, utilizing their proven excellence in study of synapse formation between T cells and tumor cells.In the I+R arm, high levels of CD4 + T cell:tumor synapse formation at baseline was associated with shorter progression-free survival and higher levels of severe infection, which likely reflects the capacity of CD4 + T cells to support tumor cell survival.However, a switch to superior CD8 + T cell:tumor synapse formation was noted at 6 and 12 months.Moreover, this was associated with improved disease control, and no comparable transition was seen in the chemotherapy treatment group.
Source: Blood
Authors: Sally Thomas, Anandi Krishnan
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4390589682