Year: 2024
Type: editorial
Abstract: This is a provisional file, not the final typeset Migraine is a common primary headache increasing prevalence that results in significant ranked as the second leading global cause of disability [1,2]. 32 Despite its high prevalence and impact, the underlying mechanisms of migraine are still not well 33 understood. Nutrition-related factors, such as the composition of one's diet and its quality, have been 34 identified as potential triggers for migraine attacks or as contributing risk factors for the development 35 of migraine [3]. However, a recent systematic review has highlighted the need for high-quality studies 36 to establish the diet-migraine association [4]. 37In light of the fact that a significant number of individuals with headache disorders discontinue 38 pharmacological treatments due to the limited efficacy and side effects [5], exploring alternative and 39 complementary strategies becomes crucial for improving patients' quality of life. 40 Therefore, this research topic aimed to showcase studies on the association between nutrition-related 41 factors and migraine and the putative mechanisms underlying this link. It conveys a collection of four 42 research articles, including one meta-analysis. 43Two studies on this research topic support the hypothesis that diet composition can contribute to 44 enhanced management of migraine headaches. In a meta-analysis of randomized controlled trials and 45 uncontrolled observational studies, Neri et al. observed an overall positive effect of ketogenic 46 interventions, including a very-low-calorie ketogenic diet, modified Atkins diet, classic ketogenic diet, 47 and the administration of an exogenous source of beta-hydroxybutyrate on reducing the frequency and 48 severity of migraine episodes. However, due to the heterogeneity of the studies, the authors reinforce 49 the need for more investigations and recommend the use of measuring ketone levels during ketogenic 50 therapy to monitor treatment adherence. 51Additionally, in a cross-sectional study, Tirani et al. demonstrated a significant inverse association 52 between the dietary diversity score (DDS) and the frequency of migraine headaches. The DDS is a 53 metric calculated based on food group consumption that can indicate diet quality and micronutrient 54 adequacy [6]. While DDS was related to attack frequency, it showed no association with severity or 55 migraine-related disability. Their observations also highlighted a negative relationship between nitric 56 oxide (NO) levels and DDS. Indeed, NO may play a role in migraine pathophysiology, and earlier 57 studies have suggested the possibility of using NO synthase (NOS) inhibitors as a therapeutic strategy 58 to alleviate migraines [7]. NO plays a pivotal role in maintaining the vascular tone among its biological 59 functions. Potassium also regulates cell membrane potential and plays a role in vascular tone. In this 60 context, the study by Xu et al. explored the relationship between potassium intake and self-reported 61 severe headaches or migraines. Xu et al. used data from the National Health and Nutrition Examination 3 This is a provisional file, not the typeset article potassium intake and reported severe headaches migraines. They identified an inflection point mg/day. According to their each 0.1g increase in daily was 65 associated with a 4.8% decrease in the likelihood of reporting severe headaches or migraines up to the 66 threshold of 1439.3 mg/day. Increasing potassium intake did not appear to provide additional benefits 67 in preventing migraines beyond this threshold. 68In a cross-sectional study, Bhering Martins et al. showed that women with migraines exhibited higher 69 resting energy expenditure (REE) than those without. This observation highlights the importance of 70 accurately assessing biological characteristics for tailored nutritional interventions for these patients 71 and suggests the association between pain and energy expenditure. REE is an important measure for 72 determining more precise nutritional interventions and can also be calculated using predictive 73 formulas. Thus, this study further assessed which predictive formulas would be most accurate for 74 evaluating the REE of women with migraine. The Mifflin-St Jeor and Henry and Rees formulas were 75 the most accurate predictive formulas for estimating REE in women experiencing migraines. 76In conclusion, these studies shed light on the potential impact of nutrition in managing migraines, 77 presenting opportunities for personalized interventions based on individual biological profiles. 78 Reference 79
Source: Frontiers in Nutrition
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,295
OpenAlex ID: W4390665264