Work

The complex heterogeneity of immune cell signatures across wasting tissues with C26 and 5-fluorouracil-induced cachexia

Year: 2024

Type: article

Abstract: Despite being an immune-driven condition, our understanding of skeletal muscle and adipose tissue immune cells with cachexia is limited. Here, we identified immune cell populations in tumors, skeletal muscle, and adipose tissue in C26 tumor-bearing mice with/without 5-fluorouracil (5FU). C26 and C26 + 5FU had increased skeletal muscle profibrotic macrophages, but 5FU reduced inflammatory myeloid cells without sparing mass. Tumor presence and chemotherapy have contrasting effects on certain immune cells, which appeared not necessary for wasting.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00548.2023

Authors: Brandon N. VanderVeen, Thomas D. Cardaci, Brooke M. Bullard, Alexander R. Huss, Sierra J. McDonald, Ahmed D. Muhammed, Jason L. Kubinak, Daping Fan, E. Angela Murphy

Institutions: University of South Carolina, University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center

Language: English

Topic: Nutrition and Health in Aging

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, NIH Office of the Director, National Cancer Institute

Awards: BD FACSymphony A5 Cell Analyzer, Harnessing the power of p53 with Panaxynol from American Ginseng to suppress colitis and prevent colon cancer, Impact of obesity on chemotherapy-induced muscle mitochondrial dysfunction, Impact of Obesity on Chemotherapy-Induced Cytotoxicity: Immune Cells and Skeletal Muscle, G8918111033, A Transdisciplinary Approach to Investigating Metabolic Dysregulation in Obese Parent and Child Dyads and Risk of Colorectal Cancer

OpenAlex ID: W4390668027

FWCI: 4.434

Cites: 40

Cited by: 19

Related to: 10