Work

BR101801 enhances the radiosensitivity of p53-deficient colorectal cancer cells by inducing G2/M arrest, apoptosis, and senescence in a p53-independent manner.

Year: 2023

Type: article

Abstract: cells. Overall, these findings provide a scientific rationale for combining BR101801 with IR as a new therapeutic strategy to overcome radioresistance induced by p53 deficiency.

Source: PubMed Central

Authors: Mijeong Park, Jimin Ha, Yuri Lee, Youngjoo Kwon, Sang Hyun Choi, Byoung Soo Kim, Youn Kyoung Jeong

Institutions: Ewha Womans University, Korea Institute of Radiological and Medical Sciences

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Korea Basic Science Institute, Korea Institute of Radiological and Medical Sciences, Ministry of Science and ICT, South Korea, Institute for Information and Communications Technology Promotion

Awards: G1530092663, G1765523463, G475672710

OpenAlex ID: W4390689814

FWCI: 0.253

Cites: 34

Cited by: 2

Related to: 10