FIGURE 1 from Analysis of Changes in Plasma Cytokine Levels in Response to IL12 Therapy in Three Clinical Trials
Year: 2024
Type: other
Abstract: Plasma cytokine levels from all patients (n = 21) measured at baseline and 72-hour post-IL12 treatment. Patient plasma samples collected 72 hours after the first, second, or third dose of IL12 were measured for levels of 23 cytokines (pg/mL). Samples were run in triplicate using seven multiplex assays. The average of the triplicates was plotted for each patient, represented by a single dot. Results shown represent the nine cytokines found to have significantly upregulated mean levels following IL12 administration. P = 0.02 for IFNγ, P = 0.02 for GMCSF, P < 0.001 for TNFα, P < 0.001 for IL18, P < 0.001 for IL10, P = 0.01 for CCL2, P = 0.001 for CCL3, P = 0.002 for CCL4, P = 0.02 for CCL8, P = 0.03 for CCL22, and P < 0.001 for CXCL10. Two-sided paired t tests, *, P < 0.05; **, P < 0.01; ***, P < 0.001.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4390694595