Work

Collecting duct water permeability inhibition by EGF is associated with decreased cAMP, PKA activity, and AQP2 phosphorylation at Ser269

Year: 2024

Type: article

Abstract: The authors used native rat collecting ducts to show that inhibition of vasopressin-stimulated water permeability by epidermal growth factor involves a reduction of aquaporin 2 phosphorylation at Ser269, a consequence of reduced cAMP production and PKA activity.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00197.2023

Authors: Chung-Lin Chou, Kavee Limbutara, Anika R. Kao, Jevin Z. Clark, Ellen H. Nein, Viswanathan Raghuram, Mark A. Knepper

Institutions: National Institutes of Health, National Heart, Lung, and Blood Institute

Language: English

Topic: Ion Transport and Channel Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute

Awards: Solute And Water Transport In Renal Epithelia, Computational Tools for Proteomics

OpenAlex ID: W4390734347

FWCI: 1.627

Cites: 79

Cited by: 12

Related to: 10