Work

Effects of aging and lifelong aerobic exercise on expression of innate immune components in skeletal muscle of women

Year: 2024

Type: article

Abstract: We recently reported that aging increases basal expression of many Toll-like receptors (TLRs) in men and lifelong aerobic exercise does not prevent this effect. In addition, a resistance exercise (RE) challenge increased the expression of many TLRs. Here we show that basal TLR expression is minimally influenced by aging in women and findings support the sexual dimorphism of immunity, with women having greater basal skeletal muscle TLR expression and a differential response to unaccustomed exercise than men.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00444.2023

Authors: Ryan K. Perkins, Kaleen M. Lavin, Ulrika Raue, Bozena Jemiolo, Scott W. Trappe, Todd A. Trappe

Institution: Ball State University

Language: English

Topic: Exercise and Physiological Responses

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Aging