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Advances in nerve guidance conduits for peripheral nerve repair and regeneration.

Year: 2023
Type: article
Abstract: Peripheral nerve injury (PNI) can cause partial or total motor and sensory nerve function, leading to physical disability and nerve pain that severely affects patients' quality of life. Autologous nerve transplantation is currently the clinically recognized gold standard, but due to its inherent limitations, researchers have been searching for alternative treatments. Nerve guidance conduits (NGCs) have attracted much attention as a favorable alternative to promote the repair and regeneration of damaged peripheral nerves. In this review, we provide an overview of the anatomy of peripheral nerves, peripheral nerve injury and repair, and current treatment methods. Importantly, different design strategies of NGCs used for the treatment of PNI and their applications in PNI repair are highlighted. Finally, an outlook on the future development and challenges of NGCs is presented.
Authors: Shasha Zheng, Hao Wei, Hong Cheng, Yanru Qi, Yajun Gu, Xiaofeng Ma, Jiaqiang Sun, Fanglei Ye, Fangfang Guo, Cheng Cheng
Institutions: Nanjing Drum Tower Hospital, Nanjing University, University of Science and Technology of China, First Affiliated Hospital of Zhengzhou University, Zhongda Hospital Southeast University, Southeast University
Language: English
Open Access status: green
Funders: Jiangsu Commission of Health, National Natural Science Foundation of China, China Postdoctoral Science Foundation, Government of Jiangsu Province, Zhengzhou University, Natural Science Foundation of Jiangsu Province, Southeast University, First Affiliated Hospital of Zhengzhou University, Natural Science Foundation of Anhui Province
Awards: G2142719017, G2236283575, G3610564235, G4444270488, G6948442762, G7435399616
OpenAlex ID: W4390792181
FWCI: 1.712
Cites: 90
Cited by: 17
Related to: 10