Embedding routine health care data in clinical trials: with great power comes great responsibility
Year: 2024
Type: article
Abstract: Randomised clinical trials (RCTs) are vital for medical progress. Unfortunately, 'traditional' RCTs are expensive and inherently slow. Moreover, their generalisability has been questioned. There is considerable overlap in routine health care data (RHCD) and trial-specific data. Therefore, integration of RHCD in an RCT has great potential, as it would reduce the effort and costs required to collect data, thereby overcoming some of the major downsides of a traditional RCT. However, use of RHCD comes with other challenges, such as privacy issues, as well as technical and practical barriers. Here, we give a current overview of related initiatives on national cardiovascular registries (Netherlands Heart Registration, Heart4Data), showcasing the interrelationships between and the relevance of the different registries for the practicing physician. We then discuss the benefits and limitations of RHCD use in the setting of a pragmatic RCT from a cardiovascular perspective, illustrated by a case study in heart failure.
Source: Netherlands Heart Journal
Institutions: Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, Erasmus MC, University Medical Center Groningen, University of Groningen, Oslo University Hospital, Werkgroep Cardiologische centra Nederland, Amphia Ziekenhuis, Netherlands Heart Registration, Karolinska Institutet, University Medical Center Utrecht, University College London
Language: English
Subfield: Health Information Management
Field: Health Professions
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4390885476