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Augmentation of Omicron BA.1 pathogenicity in hamsters using intratracheal inoculation

Year: 2024
Type: article
Abstract: The Omicron BA.1 variant of SARS-CoV-2 displays an attenuated phenotype in the Syrian hamster after intranasal inoculation. This is characterized by reduced viral replication and lung pathology in the lower respiratory tract. Here, we report that intratracheal inoculation with Omicron BA.1 recovers the lower respiratory tract replication and pathogenicity as observed with other lineages.
Source: npj Viruses
DOI: 10.1038/s44298-023-00012-2
Authors: Julia R. Port, Claude Kwe Yinda, Claire Ruckel, Jonathan E. Schulz, Brian J. Smith, Carl I. Shaia, Vincent J. Munster
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W4390918443
FWCI: 1.897
Cites: 17
Cited by: 6
Related to: 10