Work

Circulating biomarker analyses in a longitudinal cohort of patients with IPF

Year: 2024

Type: article

Study design: Observational Study

Abstract: In this study, we confirmed protein expression differences in only a subset of predicted biomarkers from IPF and control subjects. Most differentially expressed proteins were predicted to be secreted from lung cells. However, a significant minority of the proteins are not known to be transcriptionally expressed by lung cells, suggesting an ongoing systemic response. The contributions of the systemic response in IPF may be important as new therapeutics are developed.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00222.2023

Authors: Christina Ebert, Alice M. Walsh, Larisa Sereda, Carole L. Wilson, Peter H. Schafer, Aryeh Fischer, Lei Zhao, Francisco Ramirez-Valle, David Gordon, Lynn M. Schnapp

Institutions: Bristol-Myers Squibb (United States), University of Wisconsin–Madison, Medical University of South Carolina

Language: English

Topic: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Bristol-Myers Squibb, National Heart, Lung, and Blood Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: Role of pericytes in scleroderma skin and lung fibrosis, Scleroderma Twin Study and analysis of Estrogen in patients with dcSSc

OpenAlex ID: W4390918573

FWCI: 1.362

Cites: 42

Cited by: 5

Related to: 10