Absence of adverse effects of Blutaparon portulacoides (A.St.-Hil.) Mears in mice exposed during pregnancy
Year: 2024
Type: article
Abstract: Blutaparon portulacoides (A.St.-Hil.), also known as capotirguá, pirrixu, and bredo-de-praia, is a bactericidal and anti-inflammatory agent used in folk medicine to treat leukorrhea. The present study evaluated the effects of an ethanolic extract of B. portulacoides (EEBp) on the reproductive performance , embryo-fetal development, and chromosomal stability of mice of pregnant female mice treated during the gestational period with oral EEBp (500 or 1000 mg/kg) or vehicle (1% Tween 80). EEBp did not alter biometric parameters, placental index, placental efficiency, or other parameters related to reproductive performance , neither embryo-fetal development and DNA integrity, but 500 and 1000 mg/kg EEBp decreased fetal and placental weight, respectively. Although the frequency of external and skeletal malformations did not differ between these groups and the control group, EEBp increased the frequency of reduced ossification of the presphenoid and xiphoid, which can be considered variants of normality. These findings indicate that EEBp is a safe and cost-effective treatment for leukorrhea during pregnancy, although caution should be exercised in its use.
Source: South African Journal of Botany
Authors: Silvia Cordeiro das Neves, Renata Coelho Rodrigues Noronha, Antonio Carlos Duenhas Monreal, Luís Adriano Santos do Nascimento, Adauto Lima Cardoso, Flávia dos Santos Tavares, Bethânia Borges Tura, Roberto da Silva Gomes, Candida Aparecida Leite Kassuya, Viktor Krejci Nunes, Marcos José Salvador, Rodrigo Juliano Oliveira
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,750
Funders: North Dakota State University, Fundação de Amparo à Pesquisa do Estado de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação Amazônia Paraense de Amparo à Pesquisa, Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul, Universidade Federal do Pará, Universidade Federal de Mato Grosso do Sul, Foundation for Science and Technology, Fundo de Apoio ao Ensino, à Pesquisa e Extensão, Universidade Estadual de Campinas, Division 40: Society for Clinical Neuropsychology
Awards: Integrated chemical and biological study in the search for bioactive substances in plants* and development of analytical procedures. *(Amaranthaceae, Gesneriaceae, Myrtaceae e Annonaceae), G5240313103, Use of microbiome technologies and bioassays for the search for new bioactive compounds in plants and symbionts: implications for metabolic responses, molecular diversity and bioactivity, G6788781079, Search of antioxidants and antimicrobials in Gomphreneae tribe species, G8616186875
OpenAlex ID: W4390937102